Osteoprotegerin as biomarker for persistence of rheumatoid arthritis

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Osteoprotegerin as biomarker for persistence of rheumatoid arthritis

SIR, currently the treatment of RA is aimed at achieving low DAS remission. The ultimate aim, however, is to achieve DMARD-free sustained remission, which reflects the persistent absence of arthritis after cessation of treatment and is the closest proxy available for cure of RA. Although at present DMARD-free sustained remission can only be achieved in a minority of RA patients, recent data rev...

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Osteoprotegerin as biomarker for persistence of rheumatoid arthritis.

SIR, currently the treatment of RA is aimed at achieving low DAS remission. The ultimate aim, however, is to achieve DMARD-free sustained remission, which reflects the persistent absence of arthritis after cessation of treatment and is the closest proxy available for cure of RA. Although at present DMARD-free sustained remission can only be achieved in a minority of RA patients, recent data rev...

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Osteoprotegerin (OPG) as a biomarker for diabetic cardiovascular complications

Osteoprotegerin (OPG) is a glycoprotein involved in bone metabolisms and with a regulatory role in immune, skeletal and vascular systems. Recently, circulating OPG levels have emerged as independent biomarkers of cardiovascular disease (CVD) in patients with acute or chronic heart disease, as well as in the healthy population. Furthermore, OPG has been implicated in various inflammations and li...

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Serum Matrix Metalloproteinase-3 as a Noninvasive Biomarker of Histological Synovitis for Diagnosis of Rheumatoid Arthritis

OBJECTIVE To explore the correlation between matrix metalloproteinase- (MMP-) 3 and histological synovitis in rheumatoid arthritis (RA). METHODS Serum MMP-3 of 62 patients with active RA was detected by ELISA. Serial synovial tissue sections from all RA patients, 13 osteoarthritis, and 10 orthopedic arthropathies patients were stained with hematoxylin and eosin and immunohistochemically for M...

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Rheumatoid arthritis and osteoporosis

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ژورنال

عنوان ژورنال: Rheumatology

سال: 2015

ISSN: 1462-0324,1462-0332

DOI: 10.1093/rheumatology/kev415